美国杜兰大学Pisu实验室招聘博士后—生物化学和分子生物学

美国杜兰大学Pisu实验室招聘博士后—生物化学和分子生物学

Post-Doctoral Fellow, Pisu Lab

Tulane University

in New Orleans, LA

Type: Full-Time

Posted: 10/31/2025

Category: Biochemistry and Molecular Biology

Tulane University: Health Sciences: Tulane National Primate Research Center: Microbiology

Location: Tulane National Biomedical Research Center

Description:

A postdoctoral research opportunity is immediately available in the Pisu lab at the Tulane National

Biomedical Research Center to investigate macrophage heterogeneity and host-pathogen interactions

during Mycobacterium tuberculosis infection. We are seeking a highly motivated postdoctoral fellow

interested in pursuing an academic career in immunology, host-pathogen biology, and translational

infectious-disease research.

The laboratory uses murine and non-human primate (NHP) models to define how alveolar and

monocyte-derived macrophage subsets influence bacterial control and immune regulation in the lung.

Ongoing projects include NIH- and startup-funded studies examining macrophage functional diversity,

mechanisms of epigenetic and transcriptional reprogramming, and how vaccination or innate immune

training modulate susceptibility to infection.

The fellow will perform molecular, cellular, and microbiological work, including cloning,

CRISPR/Cas9 editing, RNA-seq and multiomic library preparation, flow cytometry, and microscopy,

macrophage infection assays, and murine infection studies, and will analyze the resulting datasets

using R or Python pipelines. The position offers opportunities for publication, collaboration with

multidisciplinary teams, and the development of independent research directions supported by extensive

core services and BSL-3

facilities at TNBRC.

Qualifications:

REQUIRED EDUCATION AND EXPERIENCE:

Ph.D. or equivalent in Immunology, Microbiology, or a related Biological Science.

REQUIRED KNOWLEDGE, SKILLS, ABILITIES/COMPETENCIES TYPICALLY NEEDED TO PERFORM THIS JOB

SUCCESSFULLY: (Note: The following criteria will not be used in screening qualified applicants but

may be considered in the final decision-selection process of candidates interviewed.)

1. Demonstrated proficiency in molecular and cellular biology techniques including cloning,

PCR/qPCR, CRISPR/Cas9 gene editing, and next-generation sequencing (NGS) library preparation.

2. Experience with mammalian cell culture, macrophage infection assays, and related immunological

or microbiological methods under BSL-2 conditions; readiness to obtain BSL-3 clearance.

3. Familiarity with immunological and imaging assays such as flow cytometry, cell sorting, confocal

or fluorescence microscopy, and protein quantification methods (Western blot, ELISA, Olink).

4. Competence in bacterial culture and maintenance under biosafety containment.

5. Familiarity with murine infection models, tissue processing, and immune-cell isolation under

IACUC- approved protocols.

6. Background in bioinformatics and computational biology encouraged; ability to analyze

high-dimensional data using R, Python, or equivalent platforms.

7. Strong organizational and documentation skills with adherence to biosafety and animal welfare

regulations.

8. Ability to work independently while contributing to a highly collaborative research environment.

9. Multi-year commitment to postdoctoral training.

The TNBRC maintains Biosafety Level 3 facilities and performs work on diverse infectious agents

many of which can cause serious disease in humans if standard operating procedures, including use

of appropriate personal protective equipment, are not followed. Depending on agent specific risk

assessments individuals may be offered, or in some cases required to have vaccinations against the

relevant agents.

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