美国北卡罗来纳大学教堂山分校细胞生物学、生物化学、药理学方向博士后职位

美国北卡罗来纳大学教堂山分校细胞生物学、生物化学、药理学方向博士后职位

POSTDOCTORAL RESEARCH ASSOCIATE (SNIDER LAB)

University of North Carolina at Chapel Hill

Job Description

Posting InformationPosition Title Postdoctoral Research Associate (Snider Lab)

Vacancy ID PDS002908 Department Cell Biology and Physiology - 422001 Position Type Postdoctoral Scholar

Salary Range Dependent on Qualifications/Experience

Full-time/Part-time Full Time If part-time, hours per week FTE Proposed Start Date Estimated Duration of Appointment 12 Months Posting Open Date 11/03/2020 Posting Close Date 11/13/2020 Open Until Filled No Work Location Chapel Hill, NC Position Summary

The department was formed in July 2012 through the merger of the Department of Cell & Developmental Biology and the Department of Cell & Molecular Physiology. The new department brings together two strong traditions of excellence in basic science and translational research, and in pre- and post- doctoral training, including undergraduate, graduate and medical education.

The lab of Dr. Natasha Snider studies the biology and pathophysiology of the intermediate filament (IF) cytoskeleton. Specifically, we are interested in therapeutic approaches for rare genetic diseases caused by mutations in IFs or IF-regulatory proteins. Our main goal is to prevent or alleviate the misfolding and aggregation of IF proteins that is the hallmark of these diseases. We are seeking a highly motivated postdoctoral fellow to study mechanisms of IF proteostasis and pharmacological approaches for intervention.

The project will involve development of high throughput screening (HTS) assays using primary dorsal root ganglion neurons and astrocytes from rodent models of Giant Axonal Neuropathy and Alexander Disease and validation of hits. The research also entails the use and further development of patient- derived motor neurons, astrocytes, and brain organoids of these two diseases using induced pluripotent stem cells and CRISPR/CAS9 genome editing. The work will be carried out in close collaboration with the Human Pluripotent Stem Cell Core (HPSCC) stem cell core facility at UNC.

The position will require: working with mouse and rat models of Giant Axonal Neuropathy and Alexander Disease; isolation of primary astrocytes and neurons; cell culture; pharmacological studies using FDA approved libraries, kinase inhibitors, and novel intermediate filament targeting compounds; developing biochemical and cellular assays for intermediate filaments; assaying filament properties using confocal and electron microscopy on fixed cells/tissues and in vitro assembled proteins.

Educational Requirements

Candidate must possess a PhD, MD or MD/PhD in medical science, cell biology, chemistry, biochemistry, or chemical biology.

Qualifications and Experience

Candidate should possess background and skills in cell biology, biochemistry, chemical biology, pharmacology and/or animal models of disease.

Equal Opportunity Employer

The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.

Special Instructions

For information on UNC Postdoctoral Benefits and Services click here

Quick Link https:// unc.peopleadmin.com/postings/185078 Special Physical and Mental Requirements

Department Contact Name and Title Rose Thorp, HR Consultant

Department Contact Telephone or Email rosethorp@med.unc.edu Postdoctoral Affairs Contact Information

If you experience any problems accessing the system or have questions about the application process, please contact the University's Equal Employment Opportunity office at (919)-962-1091 or send an email to equalopportunity@unc.edu.

Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.

Applicant Documents

Required Documents

  Curriculum Vitae / Resume

  Cover Letter

  List of References