波兰科学院分子机制与机器国际研究所（IMoL PAS）招聘博士后—3D肿瘤模型与生物信息学

波兰科学院分子机制与机器国际研究所（IMoL PAS）招聘博士后—3D肿瘤模型与生物信息学

Postdoctoral Researcher (3D Tumor Models and Bioinformatics)

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences (IMoL PAS)

Date Posted: Posted on 29 June 2026

Location: Poland

Job Tags:

3d tumor models, bioinformatics, computer vision, spatial transcriptomics

The International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, is a new and vibrant institute constituted in partnership with University Medical Center Göttingen, Germany and University of Warsaw, Poland. We provide innovative training, guidance and mentoring in an international “open door” environment with state-of-the-art infrastructure.

Short description of the project

The TUNIC project aims to better understand how neutrophils, the most abundant type of white blood cell, impact cancer immunotherapy. Immunotherapies like immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment, but resistance remains a challenge. The TUNIC project will investigate whether neutrophils can be targeted to enhance immunotherapy efficacy.

Current research on neutrophil function in cancer relies heavily on mouse models, which may not accurately reflect human biology due to significant species-specific differences in neutrophil biology. For example, human neutrophils contain antimicrobial proteins that are absent in mouse neutrophils. Reliance on mouse models has resulted in several failed clinical interventions for human diseases. Similarly, large-scale sequencing datasets, while informative, do not fully elucidate human neutrophil functionality.

To overcome these limitations, the TUNIC project will utilize a “phenotype-first” approach. This involves:

Creating a 3D “tumor-on-a-chip” (ToC) model: This model will incorporate primary human cells, including neutrophils, tumor cells, CD8+ T-cells, and cancer-associated fibroblasts, within a biomimetic 3D hydrogel that replicates the tumor microenvironment.

Observing neutrophil behaviour: Automated image analysis algorithms will be used to assess how different neutrophil subpopulations directly and indirectly kill tumour cells, and how this behaviour is influenced by other cells in the tumor microenvironment.

Analysing successful phenotypes: Once a neutrophil subtype with promising anti-tumor activity is identified, advanced bioinformatics-based techniques (sequencing, etc) will be employed to analyse the phenotype within ToC and other 3D models and pinpoint the functional pathways responsible for the observed phenotype.

The TUNIC project expects to identify novel therapeutic targets in neutrophils to boost immunotherapy efficacy in a clinically relevant setting. This research could pave the way for new treatment strategies that overcome immunotherapy resistance in cancer patients.

A bit about the group

At the Laboratory of Advanced Tumor Systems, we combine novel three-dimensional tumor models with primary tumor-derived cells to investigate the therapy-modulating behavior of hard-to-model cell types, such as human neutrophils. Using physiologically relevant systems, we also aim to examine the complex cellular interactions within the tumor microenvironment (TME), with the with the end goal of leveraging these insights to identify novel therapeutic targets for cancer.

Description of the tasks of the project

The hired postdoctoral researcher will be responsible for the establishment of the bioinformatics and spatial sequencing/proteomics analysis pipelines. This involves analysing sequencing (both transcriptomic and proteomic) data and creation and implementation of all the relevant computational tools. In addition, this position will also be responsible for the integration of live video imaging data and transcriptomics data, which will most likely require the development of novel bioinformatics tools and approaches.

List of specific requirements:

Ph.D. in Bioinformatics, Computational Biology, Molecular Biology, or a related field, obtained not earlier than 2013 (this is a grant requirement – this period can be increased by documented health or maternity-related leaves);

Familiarity with programming languages such as Python, R, or MATLAB;

Hands-on experience in developing and implementing bioinformatics or computer vision pipelines

Experience in sequencing data analysis (e.g., transcriptomics or proteomics), including emerging technologies (Visium, OPEN-ST, MIBI-TOF, or PhenoCycler) would be desirable;

Previous experience with either three-dimensional cancer models (organoids, tumour-on-chip, spheroids, etc) or primary neutrophils would be advantageous;

Excellent command of English, both spoken and written;

Strong organizational and project management skills;

Effective communicator with the ability to work collaboratively in interdisciplinary teams.

We offer:

Full-time position for up to 3 years with the possibility of extension;

Competitive salary ca. 9.700 PLN gross/month (for comparison, the Polish minimum salary is ca. 4.700 PLN gross/month and the average salary is ca. 9.000 PLN gross/month, and the Polish academic full professor salary is ca. 9.400 PLN gross/month);

Work in an active team in an excellent scientific environment;

Access to the state-of-the-art equipment and facilities;

Participation in courses and conferences;

Comprehensive training in biochemistry, cell and molecular biology techniques.

How to apply

Please prepare the following documents (you will be asked to submit the documents merged into one PDF file while filling out the application form linked below):

Motivation letter;

CV;

A list of publications and conferences attended;

Contact details of previous supervisors for reference (please do not attach generic reference letters, but contact details instead).

Postdoctoral Researcher (3D Tumor Models and Bioinformatics)

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences (IMoL PAS)

Date Posted: Posted on 29 June 2026

Location: Poland

Job Tags:

3d tumor models, bioinformatics, computer vision, spatial transcriptomics

The International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, is a new and vibrant institute constituted in partnership with University Medical Center Göttingen, Germany and University of Warsaw, Poland. We provide innovative training, guidance and mentoring in an international “open door” environment with state-of-the-art infrastructure.

Short description of the project

The TUNIC project aims to better understand how neutrophils, the most abundant type of white blood cell, impact cancer immunotherapy. Immunotherapies like immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment, but resistance remains a challenge. The TUNIC project will investigate whether neutrophils can be targeted to enhance immunotherapy efficacy.

Current research on neutrophil function in cancer relies heavily on mouse models, which may not accurately reflect human biology due to significant species-specific differences in neutrophil biology. For example, human neutrophils contain antimicrobial proteins that are absent in mouse neutrophils. Reliance on mouse models has resulted in several failed clinical interventions for human diseases. Similarly, large-scale sequencing datasets, while informative, do not fully elucidate human neutrophil functionality.

To overcome these limitations, the TUNIC project will utilize a “phenotype-first” approach. This involves:

Creating a 3D “tumor-on-a-chip” (ToC) model: This model will incorporate primary human cells, including neutrophils, tumor cells, CD8+ T-cells, and cancer-associated fibroblasts, within a biomimetic 3D hydrogel that replicates the tumor microenvironment.

Observing neutrophil behaviour: Automated image analysis algorithms will be used to assess how different neutrophil subpopulations directly and indirectly kill tumour cells, and how this behaviour is influenced by other cells in the tumor microenvironment.

Analysing successful phenotypes: Once a neutrophil subtype with promising anti-tumor activity is identified, advanced bioinformatics-based techniques (sequencing, etc) will be employed to analyse the phenotype within ToC and other 3D models and pinpoint the functional pathways responsible for the observed phenotype.

The TUNIC project expects to identify novel therapeutic targets in neutrophils to boost immunotherapy efficacy in a clinically relevant setting. This research could pave the way for new treatment strategies that overcome immunotherapy resistance in cancer patients.

A bit about the group

At the Laboratory of Advanced Tumor Systems, we combine novel three-dimensional tumor models with primary tumor-derived cells to investigate the therapy-modulating behavior of hard-to-model cell types, such as human neutrophils. Using physiologically relevant systems, we also aim to examine the complex cellular interactions within the tumor microenvironment (TME), with the with the end goal of leveraging these insights to identify novel therapeutic targets for cancer.

Description of the tasks of the project

The hired postdoctoral researcher will be responsible for the establishment of the bioinformatics and spatial sequencing/proteomics analysis pipelines. This involves analysing sequencing (both transcriptomic and proteomic) data and creation and implementation of all the relevant computational tools. In addition, this position will also be responsible for the integration of live video imaging data and transcriptomics data, which will most likely require the development of novel bioinformatics tools and approaches.

List of specific requirements:

Ph.D. in Bioinformatics, Computational Biology, Molecular Biology, or a related field, obtained not earlier than 2013 (this is a grant requirement – this period can be increased by documented health or maternity-related leaves);

Familiarity with programming languages such as Python, R, or MATLAB;

Hands-on experience in developing and implementing bioinformatics or computer vision pipelines

Experience in sequencing data analysis (e.g., transcriptomics or proteomics), including emerging technologies (Visium, OPEN-ST, MIBI-TOF, or PhenoCycler) would be desirable;

Previous experience with either three-dimensional cancer models (organoids, tumour-on-chip, spheroids, etc) or primary neutrophils would be advantageous;

Excellent command of English, both spoken and written;

Strong organizational and project management skills;

Effective communicator with the ability to work collaboratively in interdisciplinary teams.

We offer:

Full-time position for up to 3 years with the possibility of extension;

Competitive salary ca. 9.700 PLN gross/month (for comparison, the Polish minimum salary is ca. 4.700 PLN gross/month and the average salary is ca. 9.000 PLN gross/month, and the Polish academic full professor salary is ca. 9.400 PLN gross/month);

Work in an active team in an excellent scientific environment;

Access to the state-of-the-art equipment and facilities;

Participation in courses and conferences;

Comprehensive training in biochemistry, cell and molecular biology techniques.

How to apply

Please prepare the following documents (you will be asked to submit the documents merged into one PDF file while filling out the application form linked below):

Motivation letter;

CV;

A list of publications and conferences attended;

Contact details of previous supervisors for reference (please do not attach generic reference letters, but contact details instead).

sity of Oxford - Department of Biochemistry

Location:Oxford

Salary:£42,794 to £47,779 per annum

Hours:Full Time

Contract Type:Fixed-Term/Contract

Placed On:19th June 2026

Closes:17th August 2026

Job Ref:186874

Location: South Parks Road, Oxford OX1 3QU

About the role

Reporting to the Principal Investigator, Dr. Clinton Lau, the post holder will be a member of the Lau Lab with responsibility for carrying out research to characterise cytoskeleton-associated proteins that organise the malaria parasite, Plasmodium falciparum. The post holder provides guidance to less experienced members of the research group, including postdocs, research assistants, technicians, PhD, and project students.

This full-time fixed-term post is funded by the Wellcome Trust for up to 3 years in the first instance.

The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

About you

You will hold (or be close to completion of) a relevant PhD/DPhil, together with relevant experience. You will demonstrate a strong interest in interdisciplinary research involving cellular organisation and the ability to learn and apply specialist knowledge in areas such as structural biology, recombinant protein biochemistry and biophysics, and/or parasitology. You will bring excellent organisational and analytical skills, with the ability to independently manage your own research activities while contributing effectively within a team. Experience training and mentoring colleagues, and contributing ideas for new techniques, protocols, and research projects is essential. You will possess outstanding written and verbal communication skills, the ability to write for publication, present research, represent the research group at meetings and write accurate protocols and reports. Experience in membrane protein biochemistry, independently leading a discrete area of a research project, actively collaborating on research articles, and training others in acquired skills would be advantageous.

What We Offer

Your happiness and wellbeing at work matters to us, so we offer a range of family-friendly and financial benefits including:

An excellent contributory pension scheme

38 days annual leave

A comprehensive range of childcare services

Family leave schemes

Cycle loan scheme

Membership to a variety of social and sports clubs

Discounted bus travel and Season Ticket travel loans

The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work.

Application Process

Applications for this vacancy are to be made online via the above 'Apply' button. You will be required to upload your curriculum vitae and a supporting statement, setting out how you meet the selection criteria for the post, using examples of your skills and experience. Click here for information and advice on writing an effective Supporting Statement. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now.

For further details, please refer to the How to apply section of the job description. Any further enquires may be directed to recruitment@bioch.ox.ac.uk.

The closing date for applications is 12.00 noon on Monday 17 August 2026. Only applications received before this time can be considered. Interviews for shortlisted candidates to be held as soon as possible thereafter.

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