美国马萨诸塞大学Chan医学院Wolfe实验室招聘博士后—神经系统疾病基因组编辑方法的开发

美国马萨诸塞大学Chan医学院Wolfe实验室招聘博士后—神经系统疾病基因组编辑方法的开发

Post Doc - Open Rank - Wolfe Lab

UMass Chan Medical School

Worcester, MA

Type: Full-Time

Posted: 09/12/2025

Category: Biochemistry and Molecular Biology

Job Number: 2025-48635

Department: School - Molecular Cell & Cancer Biology - W495000

Job Type: Full-Time

Development of genome editing approaches for neurological disorders.

The Wolfe laboratory will be filling a postdoctoral position to develop improved genome editing reagents and approaches for Frontotemporal Dementia (FTD), Rett Syndrome and other monogenic disorders with the goal of translating these reagents to clinical trials. This project will focus on:

1) The development of prime editing reagents with high activity and specificity for the precise correction of common pathogenic mutations associated with FTD and Rett Syndrome.

2) The utilization of unbiased genome-wide techniques for assessing off-target events and other genomic alterations potentially associated with genome editing.

3) The translation of the developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.

These studies will expose the successful candidate to cutting-edge prime editor engineering approaches and the delivery of these reagents in vivo via AAV or lipid nanoparticles. The successful candidate will also learn cutting edge deep-sequencing approaches to evaluate off-target editing within the genome. They will have the opportunity to participate in meetings/conferences associated with genome editing and gene therapy, which will broaden their exposure to cutting edge research within the field. Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with genome editing systems, cell culture, and deep-sequencing technologies is advantageous, but not required.

Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.

Address letters to Scot Wolfe (scot.wolfe@umassmed.edu).

University of Massachusetts Chan Medical School

Department of Molecular, Cell and Cancer Biology

364 Plantation Street, LRB Room 619

Worcester, MA 01605

Further details about the Wolfe laboratory and the positions that are available can be found at https://www.umassmed.edu/Wolfe-Lab/

https://profiles.umassmed.edu/display/133161

UMass Chan Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Chan Medical School as their employer of choice.

UMass Chan Medical School welcomes all qualified applicants and complies with all state and federal anti-discrimination laws.

准备申请国外博士后的各位老师注意了！知识人网（www.zsrw.cn）小编每周定时更新最新的国内外博士后招聘信息以及访问学者、博士后资讯，感谢大家的关注！