丹麦哥本哈根大学染色体稳定性研究博士后职位

丹麦哥本哈根大学染色体稳定性研究博士后职位

Postdoctoral Research Associate In The Miller Group At The DNRF Center For Chromosome Stability

Copenhagen University

Description

The Miller laboratory in the Center for Chromosome Stability (CCS) (www. ccs.ku.dk) at the Department of Cellular and Molecular Medicine (ICMM) (www. icmm.ku.dk), University of Copenhagen, is seeking a postdoctoral research associate.

The CCS is a center of excellence funded by the Danish National Research Foundation. The successful applicant will join a newly established group studying the molecular mechanisms of eukaryotic chromosome replication using cryo-electron microscopy.

Our group and research The Miller laboratory aims to understand how eukaryotic genome stability is maintained during chromosome replication. In particular, we aim to determine the molecular mechanisms by which the replication machinery is able to overcome obstacles on eukaryotic chromosomes that might otherwise prevent replication fork progression. As well as conventional molecular biology and biochemistry, we utilize time- resolved, high-resolution cryo-electron microscopy (cryo-EM) as described in the recent study of the replicative MCM helicase loading ( Miller et al , Nature, 2019).

Start date: 1 October 2021, or as soon as possible thereafter Duration: 2 years Weekly working hours: 37

The Department The Department of Cellular and Molecular Medicine focuses on basic cellular and molecular biological processes, their regulation and their significance for cell function, interaction and organisation in tissues. The Department offers comprehensive undergraduate and graduate teaching programs spanning cell biology, genetics and basic human biology, including chemistry, biochemistry, physiology, as well as anatomy.

You can read more about the department at https: // icmm.ku.dk/english/.

Responsibilities and tasks The post-holder will biochemically reconstitute collisions between the yeast replication machinery and covalent DNA-protein crosslinks (DPCs) in vitro, which they will characterize biochemically and image by time-resolved cryo-EM.

The research will benefit from access to cutting-edge electron microscopy facilities at the Core Facility for Integrated Microscopy (CFIM) in the Faculty of Health and Medical Sciences (https: // www. cfim.ku.dk/) which houses Copenhagen's node of the Danish Cryo-EM Facility. There will also be a research-based teaching in the ICMM curriculum, including at undergraduate level.

Key criteria for the assessment of applicants

  Applicants should hold a PhD degree in biochemistry, structural biology, biophysics, protein chemistry or a related discipline.

  Applicants should have a strong background in at least one of the following areas: DNA replication or repair, protein biochemistry, electron microscopy, X-ray crystallography, single-molecule imaging or yeast genetics.

  A high level of proficiency in laboratory work.

  Evidence of an ability to publish in major international research journals.

  Problem-solving skills.

  Ability to work independently and efficiently as part of a team.

  Well organized with attention to detail and excellent record keeping.

  Strong communication skills and fluency in written and spoken English.

  Enthusiasm, motivation, and capability to learn new methods.

Place of employment The place of employment is the DNRF Center for Chromosome Stability, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.

Terms of employment Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at DKK 34,900 / approx. EUR 4,690 (April 2021-level) plus pension.

For International applicants, please read more about the working conditions: International Staff Mobility.

Application procedure Your application must be submitted electronically by clicking ‘ Apply now' below. The application must include the following documents in PDF format:

  Motivated letter of application (max. one page).

  CV incl. education, experience, language skills and other skills relevant for the position.

  PhD and Master diplomas and transcript of records

  List of publications.

Application deadline: 27July 2021, 23.59 p.m. CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

Questions For further general questions about the position, please contact Elin Oelgaard by e-mail: ee@sund.ku.dk.

The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https: // employment.ku.dk/faculty/recruitment-process/.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.