美国贝勒医学院乳腺癌研究博士后招聘

　　美国贝勒医学院乳腺癌研究博士后招聘

　　Postdoctoral Associate - Breast Center - Schiff (90003816)

　　·         Baylor College of Medicine

　　·         Location: Houston, TX

　　·         Job Number: 7067188 (Ref #: 2331-en_US)

　　·         Posting Date: Jun 24, 2020

　　·         Application Deadline: Open Until Filled

　　Job Description

　　Job Purpose

　　The laboratory of Dr. Schiff and Dr. Osborne studies key oncogenic signaling pathways for targeted therapy in breast cancer and the mechanisms of drug resistance. The lab's goal is to design and translate to the clinic, strategies that better predict, prevent, or overcome resistance by using tailored drug combinations with a favorable safety profile.

　　We are working to:

　　Investigate the genomic and epigenomic regulation of ER in hormone therapy resistance and metastasis, with a particular focus on co-regulators of ER and pioneer factors.

　　Identify the mechanisms of resistance to CDK4/6 inhibitors and develop biomarkers.

　　Determine the mechanisms by which receptor tyrosine and serine/ threonine kinases cause resistance to endocrine therapies and develop therapies to overcome resistance.

　　Characterize ER-positive and HER2-positive breast cancer molecular profiles using clinical specimens and develop multifactorial predictive biomarkers to stratify patients for tailored targeted therapies as well as treatment de-escalation.

　　Determine mechanisms of resistance to HER2-targeted therapies and design effective treatment regimens and drug combinations to overcome resistance.

　　Delineate the role of circulating tumor cell (CTC) and CTC clusters in breast cancer metastasis and therapy resistance.

　　Job Duties

　　·         Plans, directs and conducts specialized and advanced research experiments.

　　·         Evaluates and analyzes data.

　　·         May establish new research protocols and procedures.

　　·         Summarizes research findings and publish results in research journals.

　　·         May be responsible for laboratory operations.

　　·         May supervise research staff.

　　Minimum Qualifications

　　·         MD or Ph.D in Basic Science, Health Science, or a related field

　　·         No experience required

　　Preferred Qualifications

　　Cancer biology experience