英国弗朗西斯•克里克研究所（Francis Crick Institute）招收博士后

　　英国弗朗西斯·克里克研究所（Francis Crick Institute）招收博士后

　　The Francis Crick Institute

　　Location:London

　　Salary:Competitive with benefits, subject to skills and experience

　　Hours:Full Time

　　Contract Type:Fixed-Term/Contract

　　Placed On:15th June 2020

　　Closes:15th July 2020

　　Job Ref:014027

　　Location:          The Francis Crick Institute, Midland Road, London

　　Contract:          Fixed-term, 4 years

　　Short summary

　　The Treeck lab is recruiting a highly motivated postdoc to develop an independent project investigating the function of effector kinases the malaria causing parasite secretes into its host cell (see Davies & Belda et al., Nature Microbiology, 2020). The successful researcher will be enthusiastic about host-pathogen interactions and curious to understand how different parasites and species adapt to different hosts, or conditions within the host. The evolution of host-pathogen interaction occurs at many levels and requires a broad approach to understand the forces at play. We aim to understand the function of secreted kinases on an all-encompassing level, that is, from the analysis of their expression levels and genomic structure within patients in endemic countries to the detailed characterization of their individual function on the molecular level in the laboratory.

　　We offer a 4-year contract in a highly diverse lab consisting of 6 postdocs and 4 PhD students from various biological backgrounds (visit www.treecklab.org) with a strong expertise in genetics, proteomics and cell biology. The lab is located in the Francis Crick Institute (www.crick.ac.uk) in central London, where we benefit from outstanding in-house science technology platforms that support out science including, but not limited to: genomics/ proteomics/ imaging/ electron microscopy/ chemistry/ computational biology/ high throughput analysis/ structural biology.

　　Project scope

　　The aim of the project is to unravel the function of secreted parasite kinases and their role in human malaria. The candidate will join a team of researchers interested in unravelling the function of FIKK kinases and develop an independent project to investigate their function using genetic, biochemical, structural, cell biological or computational methods.

　　About us

　　The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

　　An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

　　The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines.

　　The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

　　If you are interested in applying for this role, please apply via our website.

　　A specific cover letter is required detailing your interest in the project and which particular part you are interested working on (cell biology/ structural biology/…), which skills you bring to the lab and what you would like to learn (1 Page maximum).

　　A CV

　　Three letters of recommendation

　　The closing date for applications is 15 July 2020 at 23:30.

　　All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.