美国哈佛医学院/波士顿儿童医院招收博士后

　　美国哈佛医学院/波士顿儿童医院招收博士后

　　Title: Postdoctoral Fellow and Research Scientist Positions

　　Employer: Boston Children’s Hospital / Harvard Medical School

　　Locations: 300 Longwood Ave., Boston, MA, 02115, USA

　　Two postdoctoral fellow positions and a technician/research scientist position are available in Dr. Min Dong’s lab at Boston Children’s Hospital / Harvard Medical School. Our laboratory has a broad interest in microbial toxins, bacterial pathogenesis, host-microbe interactions, and protein engineering. Along these lines of basic research, we are keen in developing microbial protein-inspired novel therapeutics for treating genetic diseases, cancer, pain, and other neurological disorders. We have a multi-disciplinary team crossing microbiology, protein engineering, cell biology, and neuroscience fields. Recent achievements include identification of receptors for C. difficile toxin via genome-wide CRISPR-Cas9 screen (Nature, 2016, 538:350, Science, 2018, 360:664), identification of novel botulinum neurotoxins (Nature Communications, 2017, 8:14130; Cell Host and Microbe, 2018, 23:169), and protein engineering of botulinum neurotoxins (Nature Communications, 2017, 8:53; Science Advances, 2019, 5:eaau7196). Please see lab website for details: http://donglab.hms.harvard.edu.

　　Potential projects include: (1) Mechanism of bacterial toxins and effectors: we are studying botulinum neurotoxins, C. difficile toxins, and many novel bacterial effectors using latest experimental approaches. (2) Host-microbe interactions and vaccine/antibody development focusing on C. difficile infection. (3) Developing novel therapeutic proteins and drug-delivery systems for genetic editing (e.g. Cas9, Cas13) and modulation of signaling networks in cells for treating genetic diseases, pain, neurological disorders, and cancer.

　　Interested candidates please forward your curriculum vitae and names of three references to Dr. Min Dong by email: donglab@childrens.harvard.edu