英国癌症研究中心计算化学博士后招聘

　　英国癌症研究中心计算化学博士后招聘

　　The Drug Discovery Unit at the Beatson Institute in Glasgow, is one of four Cancer Research UK funded Drug Discovery Units across the UK. The aim of these units is to work closely with local cancer experts to maximise the opportunity to develop new and innovative therapies that strike at the core of cancer pathology. Using state of the art screening, advanced structural biology, industry standard computational and medicinal chemistry and complex biological modelling systems, the Drug Discovery group at the Beatson is tackling some of the most challenging targets in cancer biology today. One such target that has eluded drug discovery efforts over the years is KRAS. Highly mutated in cancer, KRAS has proved difficult to target. Harnessing the significant capability of the Beatson Drug Discovery Unit we have developed a highly competitive KRAS inhibitor project.

　　An exciting opportunity has arisen within the Beatson Drug Discovery Unit to join a three year collaboration project with Novartis to develop RAS inhibitor compounds for the treatment of KRAS driven cancers for which there is a substantial unmet clinical need. https:// commercial.cancerresearchuk.org/cancer-research-uk-beatson-institute- starts-strategic-collaboration-accelerate-kras-drug-discovery This project builds on the success within the BDDU in developing KRAS inhibitors and we are now looking for an enthusiastic computational chemist to join our team to take this project to the next stage. The successful candidate will primarily support the advancement of current oncology projects within the DDU through mainly structure-based computational approaches. The candidate should have a sound knowledge of programs (such as MOE, Schrödinger and Molsoft) and computational techniques, data visualization (e.g. Dotmatics Vortex) and analysis tools (e.g. PipelinePilot, Knime) used in an industry-standard drug discovery setting.

　　Skills and Experience : Ph.D. in computational chemistry, cheminformatics or a related field Demonstrated skills in the application of computer-assisted drug design using modelling and computational software Experience in applying quantum mechanics, molecular dynamics and free energy perturbation calculations in drug design desirable Experience of working within a drug discovery environment would be an advantage Strong oral and written communication skills required Communicate and collaborate effectively with medicinal chemists, structural biologists and other members of cross-functional project teams Knowledge of one programming or scripting language (such as Python, Java, C++ and R) Good knowledge of UNIX/Linux Ability to work independently and collaboratively in a multidisciplinary, team-oriented environment Maintain and develop working knowledge of state-of-the-art computational chemistry methods and their application to drug design

　　Basic knowledge of medicinal chemistry preferred Informal enquiries are welcome and should be addressed to Dr Justin Bower (Joint Head of Drug Discovery). j.bower@beatson.gla.ac.uk Closing date for applications is 22 nd of May 2020