瑞士巴塞尔大学视网膜生物化学/细胞生物学博士后职位

　　瑞士巴塞尔大学视网膜生物化学/细胞生物学博士后职位

　　The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated Research Associate/Postdoctoral Fellow to join the Translational Group. The main goal of the Translational Group is to develop and bring new classes of therapies to the clinic. We specifically focus on gene therapy and base editing technologies to provide treatments for genetic vision loss. Our activities include developing gene editing assays, performing proof-of-concept studies in cells, organoids, retinal explants and animal models, optimizing lead candidate therapeutic agents, perform safety and biodistribution studies, characterize and recruit patients for the clinical trials, develop clinical outcome measures and prepare for regulatory authorization. The Translational Group is an interdisciplinary environment and acts as a bridge between IOB's Molecular and Clinical Center to allow rapid translation of scientific results into therapy. IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded.

　　Your position

　　  Develop organoid models of retinal disease by genetic engineering

　　  Characterize genetically engineered retinal organoids with multiple methods, including biochemical assays, metabolomics, proteomics, spatial transcriptomics

　　  Perform various microscopy techniques to phenotype organoids

　　  Develop robust assays for testing of genetic therapies in organoid models

　　  Perform proof-of-concept gene correction studies on organoids

　　  Write GLP compliant experiment reports

　　  Close collaboration with group members and IOB groups

　　  Involvement in the translation of cutting-edge precision gene therapies

　　Your profile

　　  PhD degree in biochemistry, molecular biology or related field.

　　  Minimum 5 years-experience at least in one of the following fields: biochemistry, metabolomics, proteomics, spatial transcriptomics and organoid phenotyping

　　  Independence in planning, conductance, analysis and troubleshooting complex experiments

　　  Hands-on experience to work with rodents

　　  Highly organized, precise, detail-oriented and computer skilled

　　  Good written and verbal communications skills

　　  Fluency in oral and written English

　　We offer you

　　  Highly competitive conditions in a dynamic and international research community in Basel

　　  IOB is an equal-opportunity employer with family-friendly work policies

　　Application / Contact nterested candidates should submit their application documents as a single PDF file to jobs@iob.ch by May 15th, 2020. Please indicate the position you are applying for by writing the reference number (IOB050) on the subject line. For further information, please visit our website www. iob.ch or contact Dr. Bence Gyorgy at bence.gyoergy@iob.ch (no application documents to this email).

　　www. unibas.ch