美国克利夫兰诊所招收生物化学/分子生物学博士后

　　美国克利夫兰诊所招收生物化学/分子生物学博士后

　　Cleveland Clinic

　　Location: Cleveland, OH

　　Job Number: 7065204

　　Posting Date: Mar 10, 2020

　　Application Deadline: Open Until Filled

　　Job Description

　　Alternative NHEJ Mechanisms and Targeted Therapy in Multiple Myeloma

　　Our group at the Cleveland Clinic Lerner Research Institute Cancer Biology Department is seeking a highly motivated post-doctoral fellow to join our studies to develop novel treatment and treatment prediction markers in multiple myeloma.

　　Our laboratory focuses on the critical chromosomal translocations that drive multiple myeloma development, precision medicine, and disparities. Via mechanistic dissection of B cell Class Switch Recombination (CSR) especially the error prone alternative NHEJpathway and/or somatic hyper mutation (SHM) pathway regulated by AID, we aim to develop novel therapeutic targets and treatment approaches and to identify biomarkers of response to targeted therapy. All projects involve conditional transgenic and xenograft mouse models of multiple myeloma and clinical validation of laboratory findings patient’s samples from multiple myeloma tissue bank and ongoing clinical trials.

　　The position will provide a unique and multidisciplinary exposure to preclinical mouse models, molecular oncology, immune therapy, drug development and clinical trials. Further details are available at: https://www.lerner.ccf.org/cancerbio/zhao/

　　The ideal candidate has a Ph.D. or M.D. degree in biochemistry, clinical medicine, or molecular biology; has the appropriate expertise in mouse model is highly encouraged to apply. Outstanding verbal and communication skills are required. Interested applicants should submit a CV and contact information for 3 references to Dr. Jianjun Zhao via email: zhaoj4@ccf.org.