奥地利维也纳生物中心两名博士后职位—核膜作为智能边界

奥地利维也纳生物中心两名博士后职位—核膜作为智能边界

Two Postdoctoral Positions – Nuclear Envelope as an Intelligent Boundary

Employer

Köhler Lab, Max Perutz Labs

Location

Vienna BioCenter, Austria

Salary

€69,000+ per annum (adjustable based on experience)

Closing date

20 Aug 2025

Köhler Lab, Max Perutz Labs, Vienna BioCenter

Rethinking cellular boundaries

Cellular boundaries are not passive—they are interfaces that convert spatial separation into function. Membranes, nuclear pores, and phase boundaries establish localized environments that concentrate activity, enhance specificity, and scaffold complex regulation. These interfaces don't just divide—they integrate: shaping interactions and encoding control in space and time.

The nuclear envelope exemplifies this principle. Far from a static shell, it is an intelligent boundary—an adaptive interface, not in a cognitive sense, but in its capacity to integrate genome organization, lipid metabolism, transport, and translation across nuclear and cytoplasmic domains.

The Köhler Lab invites applications for two fully funded postdoctoral positions in nuclear envelope biology and cellular stress resilience. These roles offer a unique opportunity to pursue ambitious, long-term research in a rigorous, idea-driven environment at one of Europe’s leading life science hubs.

Both positions may transition into permanent research appointments, depending on scientific vision and contribution. The position offers a minimal annual salary of € 69,000 and is adjustable based on research experience.

Research Focus

Our work centers on the nuclear envelope—a hallmark of eukaryotic evolution that integrates mechanical resilience, selective transport, lipid metabolism, and gene regulation. We investigate:

Lipid metabolism of the nuclear envelope

Nuclear pore complex architecture

Chromatin-associated signaling pathways

As one of our model systems, we use tardigrades—the toughest animals on Earth. Tardigrades’ resilience to desiccation, radiation, and temperature offers a unique opportunity to explore the limits at which cellular boundaries can operate.

Our approach

We combine biochemical reconstitution, live-cell imaging, multi-scale structural biology, and omics technologies to uncover how the nuclear envelope functions as an intelligent boundary between nuclear and cytoplasmic domains—even under extreme stress.

Recent Contributions

Lipid metabolism at the inner nuclear membrane shapes nuclear architecture

Romanauska & Köhler, Cell 2018

Phase-separated chromatin compartments for ubiquitin signaling

Gallego et al., Nature 2020

Reconstitution of the nuclear pore basket on synthetic membranes

Stankunas & Köhler, Nature Cell Biol. 2024

Engineering nuclear envelope geometries to probe lipid chemistry-function relationships

Romanauska & Köhler, Nature Cell Biol. 2023

What We Offer

Two fully funded, full-time postdoctoral positions

Possibility of transitioning to a permanent research role

Freedom to develop independent ideas within a clear and ambitious research program

Strong institutional and grant support

Access to advanced technologies: cryo-EM, imaging, proteomics, and other core facilities

A collaborative, conceptually driven lab culture

Candidate Profile

We are looking for researchers with:

A PhD in molecular biology, cell biology, biochemistry, biophysics, or a related field

Interest in membrane biology, chromatin regulation, stress resilience, or non-model organisms

Experience in biochemical reconstitution, imaging, or omics-based approaches

Intellectual curiosity, precision, and the motivation to contribute lasting insights to fundamental biology

Scientific Environment

The Max Perutz Labs (https://www.maxperutzlabs.ac.at) are part of the Vienna BioCenter (https://www.viennabiocenter.org), a major European life science campus with over 50 research groups and world-class infrastructure.

Located in Vienna—a city known for its exceptional quality of life—we benefit from robust funding and a vibrant international scientific community. English is the working language across the campus.

How to Apply

Please send your CV, a statement of research interest, and contact information for two referees to: alwin.koehler@maxperutzlabs.ac.at

Review of applications will begin immediately and continue until the positions are filled. Early applications are encouraged.

Lab website: https://www.maxperutzlabs.ac.at/research/research-groups/koehler

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