美国加州大学旧金山分校博士后项目---肺损伤和纤维化机制研究

美国加州大学旧金山分校博士后项目---肺损伤和纤维化机制研究

The laboratory of Dr. Mallar Bhattacharya at UCSF has an open position for a postdoctoral fellow interested in mechanisms of lung injury and fibrosis. The Bhattacharya Laboratory (https://bhattacharyalab.ucsf.edu) is focused on immune-stromal interactions in the lung. Our work addresses the following overarching questions: How do macrophages regulate fibroblast activation? How does cellular senescence regulate immune cell recruitment and function? A range of approaches is used, including single cell genomics, live tissue slice imaging, and functional lung injury experiments, as well as analysis of primary human lung cells. Recent papers from the lab include:

Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate A, Butte AJ, Bhattacharya M. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nature Immunology. 2019. Feb;20(2):163-172. PMID:30643263.

Lee J, Islam MI,  Boostanpour K,  Aran D, Christenson S, Matthay MA, Eckalbar W, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya, Wolters PJ, Bhattacharya M. Molecular programs of fibrotic change in aging human lung. Nature Communications. 2021. Nov 2;12(1):6309 PMID:34728633.

The UCSF community is an exciting place for immunology and translationally-focused, mechanistic research. If interested, please forward a cover letter and CV to mallar.bhattacharya@ucsf.edu.

Required qualifications:

-PhD degree in immunology, lung biology, or a related field, with direct experience with immune profiling and functional assays including flow cytometry/FACS

-Experience with mouse genetic models

-Willingness to develop a working knowledge of single-cell genomics analysis

-Knowledge of and experience with molecular biology techniques

Preferred qualifications:

-Experience with confocal or multiphoton microscopy

-Experience in lung models