英国埃克塞特大学博士后—多能性干细胞生物学

英国埃克塞特大学博士后—多能性干细胞生物学

埃克塞特大学（University of Exeter），又名埃克斯特大学，是一所位于英国西南部的顶尖公立综合性研究型大学，起源于十九世纪中叶，于1955年受皇家特许正式创建大学。现为英国罗素大学集团、英联邦大学协会和GW4联盟等组织成员。

Postdoctoral Research Associate or Fellow

University of Exeter

Faculty of Health and Life Sciences

This new full-time post is immediately available until 30 June 2026 on a fixed term basis.

Location  Exeter

Salary  The starting salary will be from £32,982 on Grade E for the Postdoctoral Research Associate role and from £41,732 on Grade F for the Postdoctoral Research Fellow role, depending on qualifications and experience.

The post

The Faculty wishes to recruit two Postdoctoral Researchers to study the biology of pluripotency in the team of Prof Austin Smith. These European Research Council funded posts are immediately available to 30 June 2026. Based in the interdisciplinary Living Systems Institute, the successful applicants will join a world-leading programme of investigations into the plasticity of the pluripotency network in different mammals. Applicants should be motivated by fundamental curiosity with a particular interest in early development and/or cell fate decision-making.

Post 1: Naïve pluripotent stem cells have to date been established only from rodents and primates. Our goal is to design signalling environments for capturing naïve pluripotent stem cells from livestock and other mammals, including marsupials. Approaches will include pluripotency network resetting and somatic cell reprogramming, as well as direct derivations from livestock embryos. This post requires cell culture aptitude, experience with genetic manipulations, and knowledge of developmental signalling.

Post 2: Mouse and human naïve pluripotent stem cells have overlapping but distinct gene regulatory networks and exhibit different direct lineage potencies. Our goal is to uncover the core gene regulatory network shared across mammalian species. Approaches will include genetic perturbations, transcriptome and chromatin analyses, and network inference. This post requires advanced skills in molecular cell genetics, ability to use basic sequencing analysis pipelines, and an interest in molecular networks.

Both posts will involve extensive stem cell culture experimentation including molecular reprogramming, genetic manipulation, signalling pathway manipulation, and targeted chemical and genetic screens. Transcriptomic and multimodal ‘omics analyses will be carried out in partnership with computational/bioinformatics members of the group.

About you

PDRA: The successful applicant will be able to present information on research progress and outcomes, communicate complex information, orally, in writing and electronically and prepare proposals and applications to external bodies.

Applicants will possess a relevant PhD (or be nearing completion) or possess an equivalent qualification/experience in a related field of study and be able to demonstrate sufficient knowledge in the discipline and of research methods and techniques to work within established research programmes.

PDRF: The successful applicant will be able to develop research objectives, projects and proposals; identify sources of research funding and contribute to the process of securing funds and make presentations at conferences and other events.

Applicants will possess a relevant PhD or equivalent qualification/experience in a related field of study. The successful applicant will be a nationally recognised authority in the subject area and possess sufficient specialist knowledge in the discipline to develop research programmes and methodologies. The successful applicant will also be able to work collaboratively, supervise the work of others and act as team leader as required.

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