美国桑福德伯纳姆普利贝斯医学发现研究所（SBP）衰老和癌症表观遗传学博士后职位

美国桑福德伯纳姆普利贝斯医学发现研究所（SBP）衰老和癌症表观遗传学博士后职位

Postdoctoral Associate (Epigenetics of Aging and Cancer) Adams Lab

Sanford Burnham Prebys Medical Discovery Institute (SBP)

Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health.

Dr. Adams’ lab investigates the impact of chromatin and epigenetics on cellular senescence, aging and cancer. In particular, the lab hypothesizes that age-associated changes in chromatin and epigenetic programming contribute to the dramatic age-associated increase in incidence of cancer. While age is the biggest single risk factor for most cancers, the reason for this is current poorly understood.

The lab strives to be highly collaborative with other labs in San Diego, the US and elsewhere, for example collaborating with computational biologists, immunologists, experts in specific mouse models of cancer and aging, and surgeons, pathologists and clinical oncologists. For more information, see http://www.padamslab.org and Twitter - @AdamsBioAging

The Adams laboratory has a Postdoctoral Associate position available.

Applications are invited from ambitious, independent and motivated candidates to join the lab of Professor Peter D. Adams investigating the the epigenetics of aging and cancer at Sanford-Burnham-Prebys Medical Discovery Institute, San Diego. The specific project in the broad epigenetics-cancer-aging area can be discussed, but possible projects include: 1) investigating age-dependent epigenetic changes that lead to increased incidence of cancer with age, for example liver cancer and breast cancer; 2) mechanism of formation of pro-inflammatory “cytoplasmic chromatin fragments (CCF)” (activators of cGAS/STING pathway) in senescent cells; 3) mechanisms and consequence of DNA methylation clocks; 4) defining mechanisms of chromatin homeostasis (“chromostasis”) that facilitate epigenetic and phenotypic stability and healthy aging; 5) epigenetic dysregulation in Acute Myeloid Leukemia that can be exploited for development of novel therapies.

The project can employ state-of-the-art molecular and cellular biology approaches, including ChIP-seq, RNA-seq, ATAC-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including at the single-cell level and spatial “-omics” at the single cell level; high throughput chemical and RNAi/CRISPR phenotypic screens; cell imaging; state-of-the-art gene manipulations using RNAi and CRISPR technology. In addition, we routinely employ sophisticated mouse models and human tissues.

San Diego is an outstanding scientific environment and a fabulous place to live.

TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments.

Primary Responsibilities

•Pro-actively and semi-independently lead a project focused on epigenetics of aging and/or cancer

•Perform cell and molecular biology experiments

•Work with mouse models of cancer and aging

•Generate hypotheses, design experiments, interpret data, trouble shoot and optimize experiments

•Collaborate and synergize with other members of the lab to promote lab synergies

•Present results to lab members at weekly lab meetings

•Present results and data within SBP, local La Jolla meeting and national and international meetings, as appropriate

•Maintain and initiate collaborations between Adams lab and other labs in SBP, San Diego, US and worldwide

Required Experience

•Candidates should have, or be working towards, a PhD or equivalent degree in a biological science

•Experience and/or expertise in an aspect of cell and/or molecular biology and/or animal models is highly desired

Knowledge, Skills and/or Abilities

•Knowledge of molecular biology of chromatin and/or epigenetics is ideal

•Knowledge of statistical methods applied to biology

•Familiarity with public bioinformatics databases and resources

•Computational expertise is an advantage, but not essential

•Communicates effectively and collaborates well with Principal Investigators and their team members

•Have strong organizational and problem-solving skills

•Possess strong attention to detail, analytical and time management skills

•Excellent data presentation, communication and interpersonal skills

•Embody the Institute’s core values of Commitment, Collaboration, Communication, Community and Compassion

The scientists at Sanford Burnham Prebys Medical Discovery Institute are making research breakthroughs in cancer, neuroscience, immunology, and children’s disease. We are also at the forefront of finding solutions for health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health.

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.