杜克大学病毒学、微生物学、免疫学博士后招聘

　　杜克大学病毒学、微生物学、免疫学博士后招聘

　　Job Description

　　The Duke Human Vaccine Institute (DHVI) is a multi-disciplinary research organization in the Duke School of Medicine/Duek University focused on basic, translational and clinical research to develop novel vaccines, therapeutics and diagnostics for infectious diseases that impact global health. The Duke Regional Biocontainment Laboratory (RBL) is a division of the DHVI that supports a specific portfolio of research programs requiring enhanced biosafety and security.

　　DHVI and the Duke RBL are recruiting highly-motivated individuals as Postdoctoral Associates to join the fight against the SARS-CoV-2 virus and the resulting disease COVID19. Specifically, DHVI investigators have developed a Pandemic Prevention Program (P3) to halt the spread of pandemic infections with rapid development of medical countermeasures. The DHVI P3 program combines world-class expertise in virology, microbiology, immunology and clinical good manufacturing practice (CGMP) to create a fully integrated platform capable of responding to pandemic threats, sucah as SARS-CoV-2. At the core of the platform is a rapid high-throughput semi-automated pipeline for isolation of pathogen-specific antibodies using single-cell sorting, RT-PCR, and antibody expression and screening (binding, avidity, function).

　　Job Responsibilities:

　　• Design, develop and execute isolation and expression of antibody sequences from COVID donor memory B cells and/or plasma cells

　　• Characterize binding, avidity, neutralization/function of isolated countermeasure candidates (antibodies).

　　• Develop and run animal models of SARS-Cov-2 infection

　　• Facilitate collaborations/interactions with the P3-COVID research teams: pathogen growth, countermeasure manufacturing and formulation, and pre-clinical safety/efficacy models.

　　• Develop and implement standard operating procedures and lead in optimization, and qualification efforts for assays and procedures.

　　• Research new products, tests, and methods and report on relative feasibility, quality, and benefits of new developments.

　　• Summarize completed protocols and studies; write scientific articles and manuscripts for publication and presentation.

　　• Mentor lab staff, students and fellows in the laboratory, as assigned.

　　• Monitor progress of research projects and coordinate with P3 Program Manager(s) to stay on budget and schedule to meet the milestones and deliverables.

　　• Training in bioethics, laboratory management, and scientific writing.

　　• Maintain accurate laboratory documentation of experiments, including raw experimental data and laboratory notebooks.